Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes. Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology.

Nov 02, 2016 · Have a deleterious mutation in BRCA1/2 or ATM, or molecular evidence of other homologous recombination deficiency; Exclusion Criteria: Active second malignancy, with the exception of curatively treated non-melanoma skin cancer, carcinoma in situ, or superficial bladder cancer At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene. .

Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology.

Oct 21, 2018 · TRITON2 (NCT02952534; target enrolment, 157 pts) is evaluating rucaparib 600 mg BID in pts with a deleterious germline or somatic alteration in BRCA1, BRCA2 or 1 of 13 other prespecified HRR genes. At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes. Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology. At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology. Oct 21, 2018 · TRITON2 (NCT02952534; target enrolment, 157 pts) is evaluating rucaparib 600 mg BID in pts with a deleterious germline or somatic alteration in BRCA1, BRCA2 or 1 of 13 other prespecified HRR genes. At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes. Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes.

Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology.

Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes.

Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes. Nov 02, 2016 · Have a deleterious mutation in BRCA1/2 or ATM, or molecular evidence of other homologous recombination deficiency; Exclusion Criteria: Active second malignancy, with the exception of curatively treated non-melanoma skin cancer, carcinoma in situ, or superficial bladder cancer

Nov 02, 2016 · Have a deleterious mutation in BRCA1/2 or ATM, or molecular evidence of other homologous recombination deficiency; Exclusion Criteria: Active second malignancy, with the exception of curatively treated non-melanoma skin cancer, carcinoma in situ, or superficial bladder cancer Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes. There are currently ongoing TRITON (Trial of Rucaparib In ProsTate IndicatiONs) studies of rucaparib in metastatic castration-resistant prostate cancer (mCRPC) for men with advanced prostate cancer. TRITON2 is a single-arm open-label Phase 2 study of men with mCRPC and specific gene alterations including BRCA, ATM and other HRD gene alterations.

Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology. At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

Oct 22, 2018 · A poster presented at the ESMO meeting in Munich has just reported data from an unplanned, preliminary analysis of data from the first 85 patients (out of a scheduled total of 150 patients) enrolled in the TRITON 2 trial of the PARP inhibitor rucaparib (Rubraca) in treatment of men with metastatic, castration-resistant prostate cancer (mCRPC) and one or more of 15 different deleterious germline or somatic alterations in prespecified homologous recombination repair (HRR) genes. Oct 21, 2018 · TRITON2 (NCT02952534; target enrolment, 157 pts) is evaluating rucaparib 600 mg BID in pts with a deleterious germline or somatic alteration in BRCA1, BRCA2 or 1 of 13 other prespecified HRR genes.

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Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology.

Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology. Oct 21, 2018 · TRITON2 (NCT02952534; target enrolment, 157 pts) is evaluating rucaparib 600 mg BID in pts with a deleterious germline or somatic alteration in BRCA1, BRCA2 or 1 of 13 other prespecified HRR genes.

There are currently ongoing TRITON (Trial of Rucaparib In ProsTate IndicatiONs) studies of rucaparib in metastatic castration-resistant prostate cancer (mCRPC) for men with advanced prostate cancer. TRITON2 is a single-arm open-label Phase 2 study of men with mCRPC and specific gene alterations including BRCA, ATM and other HRD gene alterations. Nov 02, 2016 · Have a deleterious mutation in BRCA1/2 or ATM, or molecular evidence of other homologous recombination deficiency; Exclusion Criteria: Active second malignancy, with the exception of curatively treated non-melanoma skin cancer, carcinoma in situ, or superficial bladder cancer

Nov 02, 2016 · Have a deleterious mutation in BRCA1/2 or ATM, or molecular evidence of other homologous recombination deficiency; Exclusion Criteria: Active second malignancy, with the exception of curatively treated non-melanoma skin cancer, carcinoma in situ, or superficial bladder cancer

Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology.

At the ESMO 2019 prostate cancer session Dr. Wassim Abida and colleagues presented an updated analysis of TRITON2. TRITON2 is an ongoing phase 2 study evaluating rucaparib 600 mg BID in patients with mCRPC and a deleterious germline or somatic alteration in BRCA1, BRCA2, ATM, CDK12, or other prespecified DDR gene.

Preliminary Results from TRITON2: A Phase 2 Study of Rucaparib in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Associated with Homologous Recombination Repair (HRR) Gene Alterations REFERENCES 1. Parker et al. Ann Oncol. 2015;26:v69-77. 2. NCCN Clinical Practice Guidelines in Oncology.

There are currently ongoing TRITON (Trial of Rucaparib In ProsTate IndicatiONs) studies of rucaparib in metastatic castration-resistant prostate cancer (mCRPC) for men with advanced prostate cancer. TRITON2 is a single-arm open-label Phase 2 study of men with mCRPC and specific gene alterations including BRCA, ATM and other HRD gene alterations. There are currently ongoing TRITON (Trial of Rucaparib In ProsTate IndicatiONs) studies of rucaparib in metastatic castration-resistant prostate cancer (mCRPC) for men with advanced prostate cancer. TRITON2 is a single-arm open-label Phase 2 study of men with mCRPC and specific gene alterations including BRCA, ATM and other HRD gene alterations. .

There are currently ongoing TRITON (Trial of Rucaparib In ProsTate IndicatiONs) studies of rucaparib in metastatic castration-resistant prostate cancer (mCRPC) for men with advanced prostate cancer. TRITON2 is a single-arm open-label Phase 2 study of men with mCRPC and specific gene alterations including BRCA, ATM and other HRD gene alterations. There are currently ongoing TRITON (Trial of Rucaparib In ProsTate IndicatiONs) studies of rucaparib in metastatic castration-resistant prostate cancer (mCRPC) for men with advanced prostate cancer. TRITON2 is a single-arm open-label Phase 2 study of men with mCRPC and specific gene alterations including BRCA, ATM and other HRD gene alterations. Nov 02, 2016 · Have a deleterious mutation in BRCA1/2 or ATM, or molecular evidence of other homologous recombination deficiency; Exclusion Criteria: Active second malignancy, with the exception of curatively treated non-melanoma skin cancer, carcinoma in situ, or superficial bladder cancer